| About the Lab | ||||||||
Projects
|
||||||||
| People | ||||||||
| Web resources | ||||||||
| Opportunities | ||||||||
| News | ||||||||
| Day to day | ||||||||
| Home |
Research
| Research Activities | |
 |
The research activities of the laboratory are organized around four major themes which encompass : 1) Translation : aminoacyl-tRNA synthetases and transfer RNAs. 2) DNA Structure and Transcription : nuclear receptors and general transcription factors. 3) Proteins of therapeutically importance : structure determination with subatomic resolution crystallography and structure-function relationship. 4) Bioinformatics : a transversal research activity from the genome to the 3D structure by applying molecular modeling and simulations.
|
| The Genopole Strasbourg Alsace-Lorraine : "From the Gene to the Drug" | |
|
The
French government in an effort
to boost genome and post-genome research will support a network
of biotech science park in France called Genopoles. The first
Genepole to be created was the site
of Evry south of Paris. Others
regions [ The aim of the Genopole is to develop on a large scale four interdisciplinary projects which are already initiated in the key domains of genomic and post genomic research : (i) the targeted mutagenesis of the mouse and the analysis of phenotypes indispensable to understand the physiological and pathological functions of genes (ii) the determination of 3D structures of proteins, bio-computing and molecular design / modeling to study the structure-function relationships (iii) the cataloguing of gene expression by using DNA chips technology to unravel the temporal and spatial analysis of the RNA transcript in a given biological system and (iv) the transition from the genomic target to the drug. These four approaches will be used to study on a large scale groups of genes of which the functions are of considerable interest both in fundamental biology as well as potentially interesting targets. These projects have bio-computing as a common denominator and are also involved in teaching courses centered on genome and post-genome research. They should also open the possibilities of commercial developments with the aid of the Strasbourg start-up incubator and the Bio-valley network to the Upper Rhine |
|
| Structural Genomics Project | |
|
The challenge of the new
century is to assign a structure and a function to all sequences
coming from sequencing programs. The requirement for such a
structural information for proteins with unknown function but also
for elucidating biochemical mechanism(s) is growing fast. Thus,
large-scale worldwide programs called “structural genomics” (http://www.isgo.org)
have been developed. In order to fulfill these needs, the Structural Biology and Genomics Department (LBGS – IGBMC, C. U. Strasbourg) has implemented platforms using new high-throughput technologies from gene cloning to 3D structure aiming at solving crystal structures of protein families members, alone or in complex with co-factors and protein partners, related to human health (Structural Biology and Genomics Platforms - SBGP). The Structural Biology and Genomics Department is funded by academics grants and private contracts. LBGS is part of the European Community consortium SPINE (Structural Proteomics in Europe) that consists of leading European laboratories bringing collaborative efforts to develop new methods and technologies for high-throughput structural biology. LBGS is also part of nationwide Génopole program.
|
Back to top
|
|
